joi, 15 decembrie 2011

New Food Allergy Model For Fenugreek Developed

Main Category: Nutrition / Diet
Also Included In: Allergy
Article Date: 15 Dec 2011 - 1:00 PST

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A mouse model to investigate allergy to fenugreek has been developed by Norwegian researchers. The model can also be used to study cross-reactivity to peanut, soy and lupin, major food allergens with public health relevance.

Fenugreek is a member of the legume family and is used as an ingredient in curries, chutneys and teas. Allergic reactions to fenugreek may be severe yet its presence is rarely declared in ingredient listings. There is also great concern about potential cross-reactivity with other legumes such as peanut, soy and lupin.

"Allergens that are hidden in generic terms like spices, pose a special problem for food-allergic people. Fenugreek is a well-known food ingredient in Asian dishes, and as dietary patterns are changing, we will be more exposed to fenugreek also in Norway. Mouse models are important research tools that give valuable information in the understanding of food allergies, and may contribute to develop specific therapies for these food allergies" says Nina Eriksen Vinje, researcher at the Division of Environmental Medicine at the Norwegian Institute of Public Health. Vinje is the first author of the paper published in the Scandinavian Journal of Immunology.

Cross-reactivity between peanut and fenugreek first came to attention in 2006. The Norwegian Food Allergy Register received reports about allergic reactions to food containing curry powder, and cross-reactivity between peanut and fenugreek was confirmed in two peanut-allergic patients. It has since been discovered that fenugreek gives a stronger cross-reaction to peanut than other legumes such as soy and green peas.

Mouse models

New foods need to be tested on specific food-allergy models for each potential allergen. Mice are used as they have a well-characterised immune system that resembles the human immune system, allowing researchers to study complex immune reactions. The food-allergy model for fenugreek developed by the Norwegian Institute of Public Health can also be used to understand suspected cross-reactivity to peanuts and other legumes.

Article adapted by Medical News Today from original press release. Source: Wiley-Blackwell
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miercuri, 14 decembrie 2011

Holidays Offer Plenty To Sneeze At: Dust, Nuts, Mold Trigger Allergies

Main Category: Allergy
Article Date: 14 Dec 2011 - 2:00 PST

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Getting out the boxes of holiday decorations from years gone by is a time-honored tradition. But in addition to stirring up memories, it also stirs up allergies.

"The dust from the boxes and on the decorations that have been packed away in dank basements or dusty attics is triggering reactions in my allergy and asthma patients," said Joseph Leija, MD, allergist at Gottlieb Memorial Hospital. During the allergy season (March - October) Dr. Leija is responsible for providing the official allergy count for the Midwest available at Gottlieb's Web site and phone line, and through Chicago media outlets.

Carol Leopold suffers from severe allergies and so do her 12-year-old twins. "My husband and daughter are fine but fresh Christmas trees and fur from Santa's suit make my sons and I choke up and stop breathing," she said. "I still go all out for the holidays but with three artifical trees , silk poinsettias and lots of carefully scrutinized nut-free foods," she said.

The holidays are supposed to be some of the happiest times of the year. But popular seasonal items such as fresh trees, scented air fresheners, live plants and more make the holidays miserable for many.

Here are Dr. Leija's top five tips for easy breathing this holiday season:

1 - Use an Artificial Tree

The clean fragrance from the balsam, fir and pine trees available on every corner tree lot is pleasing yet also aggravates respiratory conditions. Not only is the scent a problem, but the dust, mites and other pollutants on the live tree wreak havoc on your airways and nasal passages. "The water in the tree holder also grows stagnant and collects mold, which is detrimental to those with allergies," added Dr. Leija.

2 - Never Use Scented Candles or Home Fragrance Oils

The popularity of home fragrance products and scented specialty candles reaches its pinnacle during the holidays - and so do allergies. Unplug the electric scent distributors and take a pass on the potpourri simmering pots. "Far from creating an inviting home, the fragrance aggravates the sinuses and respiratory system so sufferers can't breathe," said Dr. Leija.

3 - Avoid Real Poinsettias and Fresh Floral Arrangements

"The moist soil encourages the growth of mold. And if there is mold in your house, you are breathing mold spores," said Dr. Leija. This causes the passageways to swell and restrict airflow and can even causes skin rashes.

4 - Keep The Humidity In Check

Warm and cool air humidifiers are up and running in many homes now that the cold, dry air is here. "Get a gauge and keep the humidity no higher than 48 to 50 percent," said Dr. Leija. "Too much humidity encourages the growth of mold, which triggers allergic reactions."

5 - Store Holiday Decorations in Large Plastic Tubs

Save yourself some sneezes next year by purchasing large resealable plastic tubs for storage of decorations. Keep them dusted during the year to avoid build up.

Article adapted by Medical News Today from original press release. Source: Loyola University Health System
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marți, 13 decembrie 2011

Few Allergies In Unstressed Babies

Main Category: Anxiety / Stress
Also Included In: Allergy
Article Date: 13 Dec 2011 - 0:00 PST

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A new study from the Swedish medical university Karolinska Institutet shows that infants with low concentrations of the stress-related hormone cortisol in their saliva develop fewer allergies than other infants. Hopefully this new knowledge will be useful in future allergy prevention. The study is published in the December paper issue of Journal of Allergy and Clinical Immunology.

The incidence of allergies in children has increased over the past few decades, especially in the West. In Sweden, 30 to 40 percent of children have some kind of allergy. A combination of environmental and lifestyle factors during pregnancy and early infancy are thought to be responsible for the sharp rise in allergic diseases.

"Psychosocial factors and the stress hormone cortisol are associated with allergic diseases," says Dr Fredrik Stenius of the Department of Clinical Research and Education at Stockholm South General Hospital. "Our study found that children with low salivary cortisol levels as infants have a lower prevalence of allergies during the first two years of life, compared to other children."

The team has previously described a link between a lower prevalence of allergies in school children and an anthroposophic lifestyle.

"And now we've found the same link in infants from families that follow anthroposophic lifestyles, and that they have relatively low levels of cortisol," adds Dr Stenius, who earned his PhD earlier in the year with a thesis on the subject.

The researchers believe that factors related to stress regulation also influence the development of infant allergies and will now monitor the infants from the neonate period and into childhood.

Article adapted by Medical News Today from original press release. Source: Karolinska Institutet
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Chronic Diseases - How To Overcome Genetic And Lifestyle Factors

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Main Category: Allergy
Also Included In: Immune System / Vaccines;  Public Health
Article Date: 12 Dec 2011 - 8:00 PST

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Concerns are being raised as to how modern lifestyles may cause physiological defense mechanisms in light of the dramatic increase of people suffering from chronic inflammatory diseases, such as allergies, asthma and irritable bowel syndrome.

Researchers have conducted a perspective foresight study along the lines of the European Science Foundation's (ESF) predictions, evaluating the challenges linked to chronic inflammatory diseases. Their findings, published in a supplement to The Journal of Allergy and Clinical Immunology (JACI), the official journal of the American Academy of Allergy, Asthma & Immunology (AAAAI), report details of 10 key areas with the highest priority for research.

Harald Renz, MD, committee chair of the Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Phillips University in Marburg, Germany comments:

"Many transmissible diseases have been effectively eradicated over the last half century, yet there has been a marked increase in the incidence of chronic inflammatory diseases.

Strategies are urgently needed to determine the causes of these chronic diseases and identify targets for therapy and prevention."

Determining the factors responsible for the development of chronic inflammatory diseases remains challenging. Even though epidemiological evidence clearly indicates environmental influence as being responsible, not everyone within these environments develops diseases; and despite the fact that susceptibility to chronic inflammatory disease evidently play an important role, genetics alone may not be the only determining factor, as susceptibility to disease in later life can be influenced by prenatal exposures. Another influencing factor that determines the likelihood of a person developing diseases like asthma and allergies in later life is whether or not a person is breastfed and exposed to microorganisms after birth.

Dr. Renz and his team from the Scientific Committee of the ESF Forward Look on Gene-Environment Interaction in Chronic Disease (GENESIS) have determined key recommendations from their study listing the highest priority for research into chronic inflammatory diseases: To understand chronic inflammatory disease, researchers should apply a global or international approach.Effective interdisciplinary research strategies must be establishedThe question of tolerance should be a main focus for researchers Therapy and prevention must be clearly distinguished in research. Large prospective cohort studies that include deep phenotyping must be made priority. Effective public-private partnerships must be developed to ensure free exchange of information. Large investments are required for infrastructure, personnel, and development of research tools. Dedicated funding must be provided for interdisciplinary research. Data collection protocols, handling, and storage need to be unified. New tools and experimental models must be developed. In addition, the committee also highlighted a series of key strategic research targets that can potentially achieve significant progress in the management of chronic diseases: Therapy and Prevention.

Due to the complexity of chronic inflammatory diseases, patient treatments need to be based on deep environmental, biological and clinical phenotyping as it is not possible to establish whether potential therapies are clinically ineffective, or just not targeted correctly without phenotyping. The committee is asking for an identification of novel biological markers to improve the classification of patients, as well as for investments in bioinformatics and systems biology in order to realize the full potential of omics data.

Key issues for prevention include selecting appropriate populations and long-term tolerability of putative long-term protective agents. Preventing allergic diseases with probiotics in the form of infant food supplements have produced mixed results in clinical studies. The term 'probiotic' should be used with caution according to the committee. Further research is required to understand the function of gut microbes in health and disease.

Large Cohort Studies.

According to the committee, researchers need to conduct large cohort studies that start prior to birth, and to fully account for the impact of how intrinsic and extrinsic factors determine each individual's probability of being healthy or develop a chronic disease when given the right environmental stimuli. These studies would evaluate biological data including clinical, genomic, and environmental factors as well as psychosocial factors such as stress. International collaborations including coverage of populations with different lifestyles and environmental exposures are important factor for such studies.

Partnerships.

The changing worldwide pattern of chronic disease to developing nations provides an opportunity to establish key factors that confer both risk and protection. The committee suggests establishing research projects in regions with low or developing risk of chronic inflammatory disease together with the establishment of parallel birth cohorts in low- and high-risk regions. It is also crucial to establish cross-disciplinary partnerships that extend further than traditional disciplines, such as epidemiology and microbiology to mathematics, ecology and virology. A key driving force for future research is to have effective private-public partnerships with an appropriate flow of information exchange between academia and industry.

Research Tools, Data Generation and Management, and Infrastructure and Personnel.

New research strategies will be required that take the diversity of the microbiome in the choice of experimental models into account as well as the potential reproducibility of results. Due to the complexity initiated by the microbiome, research will require a significant investment needed for the development of bioinformatics and systems biology approaches that are necessary to evaluate the generated datasets. It also requires an electronic infrastructure that supports integrated approaches and open collaboration.

To ensure that no over-presentations of specific disciplines are made in support of unbiased approaches, funding should be provided by panels. It also requires a new generation of biological and medical scientists who will be ready to exploit rapid developments in information technology, and who are able to use insights from a wide spectrum of scientific disciplines including fields, like finance and engineering. The committee recommends creating international graduate schools that provide specific interdisciplinary research training.

In the foreword accompanying the supplement, Lars V. Kristiansen, PhD, Science Officer, European Science Foundation, European Medical Research Councils in Strasbourg, France, and his team comment in the foreword that accompanies the supplement, saying: "The socioeconomic costs of chronic diseases are staggering and ever increasing. There is an urgent need to prioritize resources and identify the most efficient scientific and societal initiatives to be adopted. National collaboration within the European region represents the most efficient manner in which strategies for amelioration of chronic inflammatory diseases in the western world may be achieved."

Written by: Grace Rattue

Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Visit our allergy section for the latest news on this subject. The supplement called “Gene-Environment Interaction in Chronic Disease - An ESF Forward Look,” by H. Renz, I.B. Autenrieth, P. Brandtzaeg, W.O. Cookson, S. Holgate, E. von Mutius, R. Valenta, and D. Haller appears as The Journal of Allergy and Clinical Immunology, Volume 128, Supplement (December 2011) published by Elsevier. It is freely available via the JACI website. Please use one of the following formats to cite this article in your essay, paper or report:

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vineri, 9 decembrie 2011

Next Generation Allergy Vaccines To Be Developed In Finland To Create Effective And Safe Desensitation Therapies

Main Category: Allergy
Also Included In: Immune System / Vaccines
Article Date: 25 Oct 2011 - 1:00 PDT

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VTT Ventures Oy has established a spin-off which develops next generation allergy vaccines. The spin-off is called Desentum Oy, and its operations are based on a VTT patented technology. Years of research, testing and official approval cycles are still required before the vaccines are ready for launch.

VTT holds patents on gene technology which can be applied to alter the structure of an allergen, i.e. a protein causing allergy, so that it will cause less allergic symptoms than the original allergen, while remaining effective in desensitisation therapy.

"The vaccine helps to improve the protection to the allergen, thus, alleviating the symptoms. That's why we prefer to use the term vaccine, instead of medication," VTT's Senior Advisor Hans Söderlund explains. The research objective is to develop an orally administered vaccine.

The foundation for this development rests on a scientific breakthrough dating back five years to a co-operation project involving VTT, the University of Eastern Finland and HUCH Skin and Allergy Hospital. Researchers were able to determine how an IgE antibody binds an allergen and were the first to present a detailed 3D structure of this complex. This proved to be different from what scientists around the world had anticipated.

Initially, Desentum Oy will develop a product line of 20 to 25 new hypoallergens which could be used as vaccines for some of the most important allergies. These include pollens (birch, hay, common wormwood, etc.), allergens from pets, and proteins associated with food allergies (fish, nuts, apple, celery). Clinical testing of the first products is anticipated to start within the next three years.

Pekka Mattila, Desentum Oy's Managing Director, knows how to run a biotechnology company and increase its business opportunities. He was one of the founding members of the Finnzymes Group and acted as its CEO until 2010, when the company was sold to the American Thermo Fisher Scientific.

What is an allergy?

Allergies are caused by the immune reaction to normally harmless proteins - allergens - present in environment, food or consumer and medical products. Due to sensitisation, the body generates Immunoglobulin E (IgE) antibodies. Next time when these antibodies recognise the same allergen, they trigger an allergic reaction and cause symptoms in the respiratory or digestive system, or the skin. An extreme allergic reaction may cause anaphylaxis or even death.

The prevalence of allergies and allergic reactions has increased in the industrialised countries, and they are now estimated to belong to the top five most costly disease groups. In Europe, the number of people suffering from allergies is estimated to exceed 80 million, while in the US the corresponding number is 65 million. According to further estimates, half of the European population will suffer from an allergy by 2015.

In the US alone, the market for antiallergic drugs is anticipated to exceed USD 15 billion by 2015. In 2010, the estimated market for new allergy vaccines is approximately USD 700 million.

Article adapted by Medical News Today from original press release. Source: St. Jude Children's Research Hospital
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Allergies & Asthma In Children: Research Highlights New Interventions, Recommendations

Main Category: Allergy
Also Included In: Respiratory / Asthma;  Obesity / Weight Loss / Fitness;  Sleep / Sleep Disorders / Insomnia
Article Date: 07 Nov 2011 - 1:00 PST

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Asthma-Related Hospital Readmissions 50 Percent Greater in Single-Parent Households

Financial strain and competing priorities at home may contribute to greater number of hospital readmissions of children with asthma from single-parent homes compared to dual-parent households, according to a new study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

The study, performed at Cincinnati Children's Hospital Medical Center showed that children in single-parent homes were 50 percent more likely to return to the hospital within 12 months for asthma or wheezing compared to children in households with two parents. Single-parent status, annual household income less than $60,000 and time constraints within the home were linked to this increased rate of readmission.

"Parents play an important role in controlling their child's asthma and it takes time, energy and resources to follow their physician's treatment plan, including reducing triggers and consistently giving medicines," says Terri Moncrief, MD, ACAAI member.

"That's why it's important to understand the constraints on single parents and identify innovative interventions to help these parents better manage their child's symptoms and ultimately keep asthma under control."

Title: Single Parenthood, Increased Household Strain, and Child Asthma-Related morbidity

By the numbers: Uncontrolled asthma accounts for approximately 500,000 hospitalizations, 1.8 million emergency room visits and 10.5 million physician office visits every year. Asthma is the most chronic condition of childhood, accounting for 12.8 million missed school days each year.

Too Few Food Allergies Confirmed by Oral Food Challenge

Oral food challenges are the gold standard for diagnosis of food allergy, yet few physicians are using the diagnostic method, according to a study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

Among the 40,104 children surveyed, 3,339 cases of food allergy were identified. Only 61.5 percent received a formal physician diagnosis. About 15 percent of children who received a physician diagnosis underwent an oral food challenge. Children with any severe symptoms such as anaphylaxis, wheezing, trouble breathing, and low blood pressure were more frequently diagnosed by a physician, and more frequently confirmed by oral food challenge.

Authors conclude that, because a large proportion of children with convincing food allergy are not diagnosed by a physician and not given a food challenge, food allergy may be underdiagnosed in the U.S. When food allergy is suspected, ACAAI recommends patients be referred to an allergist who can determine which food allergy tests to perform, determine if food allergy exists, and counsel patients on food allergy management.

"Oral food challenge provides a definitive diagnosis which is critical to providing proper disease management and prevent unnecessary avoidance of certain foods," says Ruchi Gupta, MD, MPH, Children's Memorial Hospital, Chicago. "Physicians may not be conducting the test due to the length of time it takes, 3-6 hours, and the low reimbursement for a food challenge."

Title: Diagnosis of Childhood Food Allergy in the United States

By the numbers: Of the 12 million Americans with food allergies, three million are children. That's about one in 20 children.

Sleep Apnea Linked to Teen Obesity

Obese adolescents have an increased risk of sleep apnea or abnormal breathing during sleep, according to a study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

In one of the first studies to take a closer look at the relationship between teen obesity and sleep-disordered breathing, researchers compared overnight sleep studies of 27 obese teens with and without asthma to overnight sleep studies of 23 average weight adolescents with and without asthma. The study showed nearly 73 percent of obese children were diagnosed with sleep apnea/hypopnea syndrome (SAHS) while none of the adolescents at a healthy weight were diagnosed with SAHS.

"Research shows obesity puts kids at risk for heart disease, diabetes and high blood pressure," says allergist John Oppenheimer, MD, ACAAI Abstract Committee chair. "This study identifies the addtional potential for increased sleep apnea, and the need for a larger scale study."

Title: Sleep-Disordered Breathing in Obese and Eutrophic Adolescents, Asthmatics and not Asthmatics

By the numbers: Seven million children in the U.S. suffer from asthma. Children who are overweight are nearly 2-1/2 times more likely to have asthma than those who are not overweight.

Single Dose Flu Shot May Be Safe for Children with Severe Egg Allergy

The trivalent seasonal influenza vaccine (TIV) - that protects against three types of influenza - may be safe for children with egg allergy, according to a study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

A two-year, multi-center study is seeking to evaluate the vaccine's safety in a population of only severely egg allergic children. Interim results from the first 61 patients indicate TIV is safe to administer to egg allergic individuals irrespective of the severity of their egg allergy. These findings are consistent with the experience of 7 other TIV/H1N1 studies of egg allergic children spanning 12 years, in which a total of 185 children with severe egg allergy had also safely received influenza vaccine.

Historically, as a safety precaution, dividing the dose into a 10 percent fraction and observing for symptom development before providing the remaining 90 percent was commonplace. In the current study, all patients safely received their vaccine irrespective of the dosing method. Thus the interim data indicate a single dose is well tolerated.

"The benefits of flu shots are well-established, and clearly outweigh the risks for children with egg allergy," said allergist Matthew Greenhawt, MD, ACAAI member and assistant professor in the Division of Allergy and Clinical Immunology at the University of Michigan. "Children with food allergies are more likely to have asthma, which can increase their chance of respiratory complications from the flu. Expanding the population of children that receive flu shots will play an important role in decreasing influenza associated hospitalization, and in promoting the overall health of our children."

Title: Safe Administration of Trivalent Influenza Vaccine to Egg Allergic Children with a History of Anaphylaxis or Severe Allergy to Egg

By the numbers: Egg allergy is one of the seven most common food allergens, and affects from 1.3 to 1.6 percent of children.

Text Message Reminders Keep Kids - but Not Teens - on Track with Asthma Medication

Forgetting to take controller medication is a common challenge for children with asthma and missing doses can to lead poor asthma control. New research shows daily text message reminders can improve medication adherence for some, according to allergists who presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

In a project founded by allergist Brian Safier, MD, ACAAI member, researchers collected data from study participants ages 6 to 17 who have moderate persistent or more severe asthma and use inhaled corticosteroids. Daily text messages reminding them to take their controller medication were sent, and participants' asthma control was assessed. Two of seven participants showed improvement, and parents of children in the study found the text message reminders were valuable. The authors report, however, that text messaging did not improve adherence among teens.

"Since teens often communicate by text message, we were surprised to see this approach did not improve the consistency in which they took their medication," said allergist Jennifer S. Lee, MD, ACAAI member, Women and Children's Hospital, New York. "Text message reminders help some patients take their medication more regularly. This is a pilot study, so a larger, longer term study is needed to determine if this intervention will ultimately improve asthma control."

Title: Effect of Text Message Medication Reminders on Asthmatic Medication Adherence.

By the numbers: About one in 10 children suffer from asthma and nearly four million have had an asthma attack in the past year.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our allergy section for the latest news on this subject. To learn more about allergies and asthma, take a relief self-test or find an allergist near you visit AllergyAndAsthmaRelief.org.
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Asthma And Allergies - HRF Molecule Is A Promising Target For Treatment

Editor's Choice
Academic Journal
Main Category: Allergy
Also Included In: Respiratory / Asthma
Article Date: 04 Dec 2011 - 0:00 PST

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The histamine releasing factor (HRF) molecule has been identified by researchers at La Jolla Institute for Allergy & Immunology, as a potential target for developing novel therapies for numerous allergic reactions, including asthma. The study is published online in the Journal of Clinical Investigation.

In addition, the team, led by Toshiaki Kawakami, M.D., Ph.D., is the first to illuminate the HRF molecule in promoting asthma and some allergies, including identifying its receptor - a significant discovery that answers a vital question in the allergy research community.

Juan Rivera, M.Sc., Ph.D., deputy scientific director at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health (NIH), stated that the discoveries give novel insights on the function of HRF in allergic diseases.

Rivera explains:

"Importantly, this work advances both the understanding of how HRF contributes to susceptibility of certain individuals in developing allergic disease as well as begins to unravel the mechanisms involved. What is most encouraging is the demonstration that the effect of HRF to enhance allergic responses can be blocked, thus suggesting the possibility of new therapeutic strategies in allergic disease."

The investigation highlights the development of novel treatments based on obstructing HRF interactions with specific antibody (IgE) molecules, which have long been known to be the principal causes of allergies. Furthermore, the scientists identified two peptides (N19 and H3) as powerful treatment candidates for obstructing the HRF and IgE interactions. Peptides are protein fragments which stimulate various molecular actions. N19 and H3 prevent the interactions of the HRF and IgE molecules, thus stopping the allergic cascade in mouse models.

Dr. Kawakami, lead scientist, explained:

"Based on our preliminary studies, we believe these HRF inhibitors may provide a new, innovative therapeutic avenue for the treatment of asthma and some allergies."

Hannah Gould, Ph.D., a professor and prominent allergy researcher at King's College in London, explained that the findings improved scientific understanding in numerous vital ways.

Gould said:

"The research community has long believed that the histamine releasing factor (HRF) played some role in triggering allergic responses and asthma in certain individuals. However, the identity of the primary binding partner, the HRF receptor, the unique characteristics of the IgE in these individuals, and the mechanisms involved in HRF activity have remained elusive until the present study by Dr. Kawakami and his team.

These findings suggest a potential treatment for allergy and asthma patients who have HRF reactive IgE. We can look forward to future results of pre-clinical and clinical studies in the human system."

Over the last few decades, the prevalence of asthma has been significantly increasing, reaching epidemic levels in the United States and other developed countries. In the U.S., 20 million individuals have asthma, including 9 million children. In developed countries, 10% to 20% of the population suffer from some type of allergies - both immune system disorders and illnesses.

Mitchell Kronenberg, Ph.D., president and chief scientific officer of the La Jolla Institute, a world leader in immune system research, explained:

"There is a huge need to understand these diseases and to find therapeutic interventions. Allergies and asthma are a cornerstone of the La Jolla Institute's research activities dating back to our founding scientists, who were the discoverers of the IgE molecule in the 1960's. Dr. Kawakami's latest discovery is in keeping with our history of innovation in allergy research."

Allergic reaction occurs when the immune system starts fighting substances in the environment (allergens) that are usually harmless, such as pollen, dust, dust mites, or a medicine. When the immune system is exposed to an allergen, IgE molecules stimulate white blood cells called mast cells and basophils. These cells release histamine as well as other compounds, which produce allergy symptoms that can vary from irritating to dangerous. In asthma, allergens which are inhaled can trigger wheezing shortness of breath, coughing and airway inflammation.

According to Dr. Kawakami, the HRF molecule has been researched for numerous years and was believed to be a contributory factor in the cellular interactions leading to asthma and allergies, but the specific purpose of the HRF molecule and mode of operation was previously unclear.

Dr. Kawakami, explained:

"Nasal drainage, skin blister fluids, and some bronchial fluids were found to contain HRF secretions, so the scientific community suspected that HRF was important, but we didn't know why."

Several factors have limited HRF research, such as not being able to model HRF interactions in mice. Furthermore, Dr. Kawakami explained that progress was also slowed as a result of failure to identify the HRF receptor.

Dr. Kawakami said:

"It's very, very unusual for many years to pass between the discovery of a molecule and the identification of its receptor. In this case, 15 years had passed. Without the receptor, we couldn't understand the role of this protein in asthma and allergies."

In 2007, Dr. Kawakami and his team where the first to solve this case - identifying a subset of IgE and IgG molecules as HRF receptors. This discovery enabled Dr. Kawakami and his group to map the role of HRF in allergy activation.

In addition, the team found that substantial heterogeneity exists in the IgE molecules. Funded by NIH, the original study served as the foundation for the latest discoveries on HRF's role in activating allergies. Dr. Kawakami said:

"The differences were big in terms of affecting the activation and survival of mast cells. That's why we got interested in this molecule (HRF). Earlier studies had suggested that HRF does not bind to IgE molecules. But I was not convinced, so I decided to explore this further."

According to their findings, 20% to 30% of IgE molecules can interact with HRF molecules and generate mast cell activation leading to allergies.

Dr. Kawakami, said:

"We think HRF is important for amplifying allergic reactions initiated by IgE
and an allergen."

The discoveries are published in the report entitled, Proinflammatory role of histamine-releasing factor in mouse models of asthma and allergy.

Written by Grace Rattue
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Visit our allergy section for the latest news on this subject. "Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy"
H. Matho, Dirk M. Zajonc, Tomomitsu Ozeki, Chisei Ra, Susan M. MacDonald, Reuben P. Siraganian, David H. Broide, Yuko Kawakami, Toshiaki Kawakami
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Scientists Identify Strategies To Conquer Lifestyle And Genetic Factors Related To Chronic Diseases

Main Category: Genetics
Also Included In: Allergy;  Immune System / Vaccines
Article Date: 08 Dec 2011 - 2:00 PST

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A dramatic increase in the incidence of chronic inflammatory diseases such as asthma, allergy, and irritable bowel syndrome, has led to concern about how modern lifestyles may trigger physiological defense mechanisms. Now, in the context of a foresight study under the auspices of the European Science Foundation (ESF), a group of scientists has examined the challenges associated with chronic inflammatory diseases, and described 10 key areas with the highest priority for research. Their recommendations are published in a supplement to The Journal of Allergy and Clinical Immunology (JACI), the official journal of the American Academy of Allergy, Asthma & Immunology (AAAAI).

"Many transmissible diseases have been effectively eradicated over the last half century, yet there has been a marked increase in the incidence of chronic inflammatory diseases," says committee chair Harald Renz, MD, of the Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Phillips University, Marburg, Germany. Strategies are urgently needed to determine the causes of these chronic diseases and identify targets for therapy and prevention."

Factors responsible for the development of chronic inflammatory diseases are not easily determined. While epidemiological evidence clearly points to an environmental influence, not all individuals in these environments develop disease. Susceptibility to chronic inflammatory disease has a clear genetic component, but genetics may not be the only determining factor. Prenatal exposures can influence later susceptibility to disease. After birth, factors such as breastfeeding and exposure to microorganisms appear to further influence the likelihood of developing diseases such as asthma and allergy.

Dr. Renz and his colleagues on the Scientific Committee of the ESF Forward Look on Gene-Environment Interaction in Chronic Disease (GENESIS) identified the following 10 key recommendations as having the highest priority for research into chronic inflammatory diseases:

1. Research should distinguish between therapy and prevention.

2. Large prospective cohort studies including deep phenotyping should be made a priority.

3. Research should focus on the question of tolerance.

4. A global (international) approach should be taken to understanding chronic inflammatory disease.

5. Effective interdisciplinary research strategies must be established.

6. New tools and experimental models must be developed.

7. Protocols for data collection, handling, and storage need to be harmonized.

8. Substantial investment must be made in infrastructure, personnel, and development of research tools.

9. Dedicated funding must be provided for interdisciplinary research.

10. Effective public-private partnerships must be developed to ensure free exchange of information.

Furthermore, the committee pointed to a series of key strategic research targets for which significant progress in the management of chronic diseases may be achieved.

Therapy and Prevention. Given the complexity of chronic inflammatory diseases, therapies must be based on deep environmental, clinical and biological phenotyping of patients. Without deep phenotyping, it is impossible to determine whether a potential therapy is clinically ineffective or simply inappropriately targeted. The committee calls for the identification of novel biological markers to enhance patient stratification, and for investments in bioinformatics and systems biology to realize the full potential of omics data.

For prevention, key issues include the selection of appropriate populations and the long-term tolerability of putative long-term protective agents. The results of clinical studies of probiotics as infant food supplements to prevent allergic disease have been mixed. The committee recommends that the term probiotic be employed with caution, and that further research be done to understand the function of gut microbes in health and disease.

Large Cohort Studies. The committee calls for large cohort studies, initiated prior to birth, to fully take into account the impact of how intrinsic and extrinsic factors determine the probability that an individual will be healthy or develop a chronic disease, given the right environmental stimuli. Such studies would analyze biological data including genomic, clinical, and environmental factors, and also psychosocial factors such as stress. It will be important to ensure international collaboration and coverage of populations with different lifestyles and environmental exposures.

Partnerships. The shifting global pattern of chronic disease to developing nations offers an opportunity to identify key factors that confer both risk and protection. The committee recommends that research projects be established in regions with low or developing risk of chronic inflammatory disease, and the establishment of parallel birth cohorts in low- and high-risk regions. Cross-disciplinary partnerships will be essential as well, extending beyond traditional disciplines such as epidemiology and microbiology to mathematics, virology, and ecology. Finally, effective private-public partnerships, with more fluid exchanges of information between academia and industry, will be a key driving force for future research.

Research Tools, Data Generation and Management, and Infrastructure and Personnel. New research strategies that consider the diversity of the microbiome in the choice of experimental models and the potential reproducibility of results will be needed. Because of the complexity introduced by the microbiome, substantial investment will be required to develop the bioinformatics and systems biology approaches required to analyze the datasets generated. An electronic infrastructure to support integrated approaches and open collaboration will be necessary. Funding should be made by panels in which no specific discipline is over-represented to support unbiased approaches. And, a new generation of biological and medical scientists will need to be ready to exploit rapid developments in information technology. They will need to use insights from a range of scientific disciplines as well as fields as diverse as finance and engineering. The committee suggests the creation of international graduate schools to provide specific training in interdisciplinary research.

In the foreword accompanying the supplement, Lars V. Kristiansen, PhD, Science Officer, European Science Foundation, European Medical Research Councils, Strasbourg, France, and colleagues comment, "The socioeconomic costs of chronic diseases are staggering and ever increasing. There is an urgent need to prioritize resources and identify the most efficient scientific and societal initiatives to be adopted. National collaboration within the European region represents the most efficient manner in which strategies for amelioration of chronic inflammatory diseases in the western world may be achieved."

Article adapted by Medical News Today from original press release. Source: Elsevier
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Asthma Control And Anaphylaxis Guidelines: Improving Outcomes For Adults With Allergies And Asthma

Main Category: Allergy
Also Included In: Statins;  Respiratory / Asthma;  Depression
Article Date: 07 Nov 2011 - 1:00 PST

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Cholesterol-lowering Drugs May Worsen Asthma

Cholesterol-lowering medications may help millions fight heart disease, but this class of drugs may worsen asthma control, according to a study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

In the preliminary study researchers compared 20 patients with asthma taking prescribed cholesterol-lowering medication or statins, to 20 patients with asthma who did not take the drugs. The researchers found the patients taking statins had more airway inflammatory obstruction at three, six and 12 months compared to those not on statins.

"The research showed patients taking statins more frequently used their rescue medication, had increased nighttime awakenings and had increased asthma symptoms throughout the day," said allergist Safa Nsouli, MD ACAAI member and director of Danville Asthma and Allergy Clinic, Calif. "These potential effects of statins on the inflmmatory cascade of asthma indicate the need for a larger scale study."

Title: The Correlation of Cholesterol Lowering Statin Drugs and Worsening Asthma Control in Mild Persistent Asthmatics

By the numbers: Nearly 25 million Americans have asthma. About 68 million Americans have high cholesterol.

Depression and Emotional Well-being Affect Seniors' Asthma Related Control and Quality of Life

Depression and emotional well-being greatly affect asthma control and quality of life for the approximately 2 million adults over 65 who have been diagnosed with asthma, according to a new study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

Researchers assessed the quality of life of 70 participants over the age of 65 who had been diagnosed with asthma. Quality of life measures included the number of asthma attacks and unscheduled physician visits within 12 months, self-reported depression, body mass index and confidence in managing their asthma.

The study showed depression and poorer physical and emotional status were associated with lower quality of life for participants in addition to the traditional indicators of poor asthma control.

"A more integrative approach is necessary in treating older adults with asthma," says allergist Jacqueline Ross, MD, ACAAI member. "If we treat the physical aspects of the disease as well as the psychological and social aspects, we may find greater success in asthma control and improved quality of life for seniors."

Title: Factors Associated with Asthma Quality of Life and Control among Older Adults

By the numbers: Of the nearly 25 million Americans with asthma, more than 2.5 million are 65 or older. In 2009, more than 1 million of them had an asthma attack or episode.

Treatment Guidelines Not Followed After Food-Induced Anaphylaxis

National guidelines recommend that patients who go to the emergency department for food-induced anaphylaxis, a life-threatening event, should fill an epinephrine auto-injector prescription after discharge and follow up with an allergist. The number of people who actually follow these recommendations is low, according to a study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

In the first year after food-induced anaphylaxis, among 1,370 adults, researchers found just 55 percent filled an epinephrine autoinjector prescription and only 22 percent saw an allergist.

"It's important for anyone who experiences anaphylaxis to follow up with an allergist to have the allergen identified, learn how to use self-injectable epinephrine and discuss scenarios when its use is needed," says Carlos Camargo, MD, associate professor of Medicine, Harvard Medical School. "More research is needed to understand whether physicians need more education about anaphylaxis or if patients need interventions to ensure guidelines are followed. Either way, we need to improve anaphylaxis care to prevent future life-threatening reactions."

Title: A Retrospective Database Study of Concordance with Recommended Post-Discharge Anaphylaxis Care among US Adults Seen in the Emergency Department or Hospital with Food-Induced Anaphylaxis

By the numbers: About 6 percent of young children and 3 to 4 percent of adults have food allergies in the United States. Every year between 150 and 200 people die as a result of food allergies.

Stung by Poor Management of Insect-Sting Reactions

In a community hospital emergency department, adherence to the national guidelines for treating insect-sting anaphylaxis, a life-threatening event, is low, according to a study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8.

Researchers reviewed the records of 45 patients with insect-induced anaphylaxis and found only 35 percent received epinephrine either administered by emergency medical services before arrival or while in the emergency department. In addition, just 33 percent of patients received a prescription for self-injectable epinephrine at the time of discharge and none were referred to an allergist.

"Physicians and healthcare professionals know the emergency department (ED) is the most common medical setting for diagnosing and treating anaphylaxis. However, we need to realize that advances in anaphylaxis management will only be achieved if ED staff follows the established guidelines for diagnosis and management of anaphylaxis," says allergist M. Razi Rafeeq, MD, ACAAI fellow. "This study demonstrates an opportunity for allergists to communicate and join forces with ED staff to guide patients with potentially life-threatening allergies toward better allergy management."

Title: Emergency Department Management of Insect-Sting Allergic Reactions in a Community Hospital

By the numbers: About 2 million Americans are allergic to insect stings. Each year, 500,000 end up in hospital emergency rooms after stings and 50 die.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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American College of Allergy, Asthma, and Immunolog. (2011, November 7). "Asthma Control And Anaphylaxis Guidelines: Improving Outcomes For Adults With Allergies And Asthma." Medical News Today. Retrieved from
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